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Diflucan (Fluconazole) medicine is used to treat the fungal infection of the vagina (also called, vaginal candidiasis). This drug works by preventing the formation of an enzyme (ergosterol) which is necessary for the synthesis of the fungal cell wall. Diflucan Tablet is also used to treat fungal infection of the mouth, throat, and pharynx,  to treat brain and spinal cord infection (cryptococcal meningitis) in AIDS patients, to prevent fungal infection in patients undergoing bone marrow transplantation who receive radiation therapy and chemotherapy, to treat urinary tract infection, to treat inflammation of membrane that covers abdominal organs (peritonitis), to treat pneumonia, to treat fungal infection of the blood (candidemia), to treat fungal infection of internal body organs such as liver, kidney, brain, and heart (disseminated candidiasis), and to treat fungal inflammation of penis head (candidal balanitis).

Diflucan Missing Dose

A missed dose should be taken as early as you remember it. However, if the time for the next dose is almost there, then the missed dose should be skipped, and the regular dosing schedule should be continued.


Do not take more than the prescribed dose. If you have taken more than the recommended dose of Diflucan get medical advice immediately. If necessary, the toxic effect can be reduced by cleaning out the contents of the stomach (gastric lavage). Removal of Diflucan may be increased by excessive urine formation (forced diuresis) and removing waste products from the blood (hemodialysis).

Diflucan Side-effects

The following side-effects may commonly occur when using Diflucan Tablet. If any of these side-effects worsen or last for a long time, you should consult with your doctor:

  • abdominal pain
  • diarrhea
  • headache
  • increased level of alanine aminotransferase
  • increased level of aspartate aminotransferase
  • increased level of blood alkaline phosphatase
  • indigestion
  • nausea
  • rash
  • vomiting

The following side-effects may commonly occur in older patients on the use of Diflucan Tablet. Discuss with your doctor if any of these side-effects last for a long time or are severe: Rarely, the use of Diflucan Tablet may cause the following side-effects: abnormal sensation in the body, change in the sense of taste, decreased appetite, dizziness, drug reaction of the skin (drug eruption) dry mouth, face swelling, fatigue, the feeling of discomfort, gas formation (flatulence), hair loss, hives, increased sweating, indigestion (dyspepsia), insomnia, muscle pain, severe itching, swelling of the lower layer of the skin, weakness.

Diflucan Precautions 

Before you use Diflucan, tell your doctor of your medical and health history including the following: Before you use Diflucan, tell your doctor if you are allergic to it or its ingredients. Discuss with your doctor if you are allergic to other azoles. The use of Diflucan Tablet may change transaminases and alkaline phosphatase. This medicine should be used with caution in patients with abnormal liver function. Careful monitoring of liver enzymes is required in such patients.

Use when Pregnant: Consult with your doctor on the use of Diflucan during pregnancy or if you are planning to become pregnant. Using high doses of Diflucan in women during their first 3 months of pregnancy can cause birth defects among infants. The features seen in the infants were: flat head syndrome (brachycephaly), abnormal facies, abnormal skull development, splits in the roof of the mouth (cleft palate), bow-leggedness (femoral bowing), thin ribs and long bones, birth defect of shortened joint (arthrogryposis), and birth defect of structure of the heart (congenital heart disease).

Seizures: Diflucan can make you feel sleepy. Be careful, especially while driving, while using heavy machinery, or when doing any activity that needs you to be completely alert. The consumption of alcohol with Diflucan can worsen the sleepiness. Diflucan may cause seizures in some people. Hence, you should discuss with your doctor before performing any activities where a loss of consciousness may cause harm to you or others.

Side-effects in Older Patients: Older patients may have a higher incidence of side-effects when using Diflucan Tablet. Elderly patients may see an increased risk of the reduced functioning of the kidney.

Side-effects in Children: Younger patients may have a higher incidence of side-effects with Diflucan Tablet. Younger patients may see an increased risk of vomiting, abdominal pain, nausea, diarrhea, increased levels of transaminases, and increased levels of alkaline phosphatase.

Interactions with Diflucan

When two or more medicines are taken together, it can change how the medicines work and increase the risk of side-effects. In medical terms, this is called a Drug Interaction. Do not start, stop, or change the dose of any medicines without the approval of your doctor.


There may be an interaction of Diflucan with anticoagulants, which are used to prevent blood clot formation. When Diflucan is used with anticoagulants such as coumarin and warfarin, it can cause bleeding problems such as skin injury that results in discoloration of the skin (bruising), bleeding from nasal cavity (epistaxis), stomach and intestinal bleeding, presence of blood in urine (hematuria), and black tarry stools (melena). These bleeding problems have been reported in along with increasing the blood clotting time in such patients. In such patients, time taken by the blood to clot (prothrombin time) should be monitored carefully.


Diflucan Tablet interacts with phenytoin, which is used to treat epilepsy. When Diflucan is used with this medicine, it increases the level of phenytoin in the blood. Such patients should be monitored carefully for elevated phenytoin levels.

Antifungal Drugs

Diflucan Tablet may interact with voriconazole, which is used to treat fungal infections. Monitoring of side-effects and damage related to voriconazole is recommended, particularly when voriconazole is started within 24 hours of the last dose of Diflucan. Using both the medicines together should be avoided.


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